Integrin Beta 4 (ITGb4) Antibody
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Catalogue No: abx015900
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US$427.75
(Size: 100 µl)
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Datasheet SDS
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors.Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities.Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth.This gene encodes the integrin beta 4 subunit, a receptor for the laminins.This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma.Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia.Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Research Articles on Integrin Beta 4 (ITGb4)
| Target | Integrin Beta 4 (ITGb4) |
| Research Area | Cellular Differentiation and Adhesion, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human ITGB4 (AA: 1619-1822) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P16144 (UniProt, ExPASy) |
| UniProt Entry Name | ITB4_HUMAN |
| Gene Symbol | ITGB4 |
| GeneID | 3691 |
| OMIM | 131800 |
| HGNC | 6158 |
| KEGG | hsa:3691 |
| Ensembl | ENSG00000132470 |
| String | 9606.ENSP00000200181 |
| Molecular Weight | 202 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |