Integrin Beta 4 (ITGb4) Antibody

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors.Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities.Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth.This gene encodes the integrin beta 4 subunit, a receptor for the laminins.This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma.Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia.Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Target	Integrin Beta 4 (ITGb4)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human ITGB4 (AA: 1619-1822) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P16144 (UniProt, ExPASy)
UniProt Entry Name	ITB4_HUMAN
Gene Symbol	ITGB4
GeneID	3691
OMIM	131800
HGNC	6158
KEGG	hsa:3691
Ensembl	ENSG00000132470
String	9606.ENSP00000200181
Molecular Weight	202 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Integrin Beta 4 (ITGb4)

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