Junction Plakoglobin (JUP) Antibody

JUP Antibody is a Rabbit Polyclonal antibody against JUP. This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008].

Target	Junction Plakoglobin (JUP)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human γ-Catenin.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P14923 (UniProt, ExPASy)
UniProt Secondary AC	Q15093, Q15151, Q7L3S5, Q86W21, Q9BWC4, Q9HCX9
UniProt Entry Name	PLAK_HUMAN
Gene Symbol	JUP
GeneID	3728
NCBI Accession	NP_002221.1
KEGG	hsa:3728
String	9606.ENSP00000377508
Molecular Weight	Calculated MW: 82 kDa Observed MW: 82 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Junction Plakoglobin (JUP)

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