Potassium Voltage-Gated Channel Subfamily H Member 2 (KCNH2) Antibody

KCNH2 Antibody is a Rabbit Polyclonal antibody against KCNH2. This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.

Target	Potassium Voltage-Gated Channel Subfamily H Member 2 (KCNH2)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 850-950 of human KCNH2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q12809 (UniProt, ExPASy)
UniProt Entry Name	KCNH2_HUMAN
Gene Symbol	KCNH2
GeneID	3757
NCBI Accession	NP_000229.1
KEGG	hsa:3757
String	9606.ENSP00000262186
Molecular Weight	Calculated MW: 127 kDa Observed MW: 148 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Potassium Voltage-Gated Channel Subfamily H Member 2 (KCNH2)

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