ATP-Sensitive Inward Rectifier Potassium Channel 11 (KCNJ11) Antibody
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Catalogue No: abx034279
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(Size: 80 µl)
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Datasheet SDS
ATP-sensitive potassium (K (ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K (ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.
Research Articles on ATP-Sensitive Inward Rectifier Potassium Channel 11 (KCNJ11)
| Target | ATP-Sensitive Inward Rectifier Potassium Channel 11 (KCNJ11) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNJ11. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q14654 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DWI4, E9PNK0, Q2M1H7, Q58EX3, Q8IW96 |
| UniProt Entry Name | KCJ11_HUMAN |
| Gene Symbol | KCNJ11 |
| GeneID | 3767 |
| OMIM | 600937 |
| HGNC | 6257 |
| KEGG | hsa:3767 |
| Ensembl | ENSG00000187486 |
| String | 9606.ENSP00000345708 |
| Molecular Weight | Calculated MW: 43.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rabbit KCNJ11. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |