Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11) Antibody

KCNJ11 Antibody is a Rabbit Polyclonal antibody against KCNJ11. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Target	Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 171-390 of human KCNJ11.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14654 (UniProt, ExPASy)
UniProt Secondary AC	B4DWI4, E9PNK0, Q2M1H7, Q58EX3, Q8IW96
UniProt Entry Name	KCJ11_HUMAN
Gene Symbol	KCNJ11
GeneID	3767
NCBI Accession	NP_000516.3
KEGG	hsa:3767
String	9606.ENSP00000345708
Molecular Weight	Calculated MW: 44 kDa Observed MW: 31-43 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11)

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