ER Lumen Protein-Retaining Receptor 2 (KDELR2) Antibody

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].

Target	ER Lumen Protein-Retaining Receptor 2 (KDELR2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human KDELR2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P33947 (UniProt, ExPASy)
UniProt Secondary AC	A4D2P4, Q6IPC5, Q96E30
UniProt Entry Name	ERD22_HUMAN
Gene Symbol	KDELR2
GeneID	11014
OMIM	609024
HGNC	6305
KEGG	hsa:11014
String	9606.ENSP00000258739
Molecular Weight	Calculated MW: 24.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Xenopus KDELR2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ER Lumen Protein-Retaining Receptor 2 (KDELR2)

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