Lysine-Specific Demethylase 3A (KDM3A) Antibody

This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and a-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation.In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.

Target	Lysine-Specific Demethylase 3A (KDM3A)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human KDM3A expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y4C1 (UniProt, ExPASy)
UniProt Secondary AC	D6W5M3, Q53S72, Q68D47, Q68UT9, Q6N050, Q8IY08
UniProt Entry Name	KDM3A_HUMAN
Gene Symbol	KDM3A
GeneID	55818
OMIM	611512
HGNC	20815
Ensembl	ENSG00000115548
String	9606.ENSP00000386660
Molecular Weight	147 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Lysine-Specific Demethylase 3A (KDM3A)

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