Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Antibody

Catalogue No: abx001423
Price: £120.00
(Size: 20 µl)
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Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Antibody Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Antibody

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KIR2DL3 Antibody is a Rabbit Polyclonal antibody against KIR2DL3. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].

Target KIR2DL3
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human KIR2DL3.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P43628 (UniProt, ExPASy)
UniProt Secondary AC O43472, P78402, Q14944, Q14945, Q9UM51, Q9UQ70
UniProt Entry Name KI2L3_HUMAN
Gene Symbol KIR2DL3
GeneID 3804
KEGG hsa:3804
String 9606.ENSP00000342215
Molecular Weight Calculated MW: 27 kDa, 37 kDa
Observed MW: 45 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Antibody

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