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Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) Antibody

Catalogue No: abx001361
Price: £120.00
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Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) Antibody

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KIR3DL1 Antibody is a Rabbit Polyclonal antibody against KIR3DL1. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Target KIR3DL1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human KIR3DL1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P43629 (UniProt, ExPASy)
UniProt Secondary AC O43473, Q14946, Q16541
UniProt Entry Name KI3L1_HUMAN
Gene Symbol KIR3DL1
GeneID 3811
KEGG hsa:3811
String 9606.ENSP00000375608
Molecular Weight Calculated MW: 38 kDa, 49 kDa
Observed MW: 48 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) Antibody

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