Metastasis-Suppressor KiSS-1 (KISS1) Antibody

KISS1 Antibody is a Rabbit Polyclonal antibody against KISS1. This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.

Target	Metastasis-Suppressor KiSS-1 (KISS1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 40-138 of human KISS1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15726 (UniProt, ExPASy)
UniProt Secondary AC	A8K6N0, Q9HBP1
UniProt Entry Name	KISS1_HUMAN
Gene Symbol	KISS1
GeneID	3814
NCBI Accession	NP_002247.3
KEGG	hsa:3814
String	9606.ENSP00000356162
Molecular Weight	Calculated MW: 15 kDa Observed MW: 15 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Metastasis-Suppressor KiSS-1 (KISS1)

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