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NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody
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Catalogue No: abx217181
Price:
US$406.00
(Size: 100 µg)
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NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody is a Rabbit Polyclonal antibody for the detection of KLRK1. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
Research Articles on NKG2-D Type II Integral Membrane Protein (KLRK1)
| Target | NKG2-D Type II Integral Membrane Protein (KLRK1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | NKG2-D type II integral membrane protein |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P26718 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K7K5, A8K7P4, Q9NR41 |
| UniProt Entry Name | NKG2D_HUMAN |
| Gene Symbol | KLRK1 |
| GeneID | 22914 |
| OMIM | 611817 |
| HGNC | 18788 |
| KEGG | hsa:100528032 hsa:22914 |
| Ensembl | ENSG00000213809 |
| String | 9606.ENSP00000480609 |
| Molecular Weight | Observed MW: 30 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |