Importin Subunit Alpha-2 (KPNA2) Antibody

KPNA2 Antibody is a Rabbit Polyclonal antibody against KPNA2. The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008].

Target	Importin Subunit Alpha-2 (KPNA2)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human KPNA2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P52292 (UniProt, ExPASy)
UniProt Secondary AC	B9EJD6, Q53YE3, Q6NVW7, Q9BRU5
UniProt Entry Name	IMA1_HUMAN
Gene Symbol	KPNA2
GeneID	3838
NCBI Accession	NP_002257.1
KEGG	hsa:3838
String	9606.ENSP00000438483
Molecular Weight	Calculated MW: 58 kDa Observed MW: 55 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Importin Subunit Alpha-2 (KPNA2)

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