KSHV ORF45 Antibody
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Price:
US$420.50
(Size: 100 µl)
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Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma- (2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease.The genome of KSHV is 165-170 kb and contains at least 88 open reading frames.ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells.Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7.In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN.Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions.
Target |
KSHV ORF45 |
Clonality |
Monoclonal |
Reactivity |
Virus |
Tested Applications |
ELISA, IHC |
Host |
Mouse |
Recommended dilutions |
ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Purified recombinant fragment of KSHV ORF45 expressed in E. coli. |
Isotype |
IgG1 |
Form |
Liquid |
Purification |
Unpurified ascites. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
GeneID |
4961474
|
Buffer |
Ascitic fluid containing 0.03% sodium azide. |
Concentration |
Not determined. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on KSHV ORF45