LCK (pY505) Antibody

LCK (pY505) Antibody is a Rabbit Polyclonal antibody against LCK (pY505). This gene is a member of the Src family of protein tyrosine kinases (pYKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.

Target	LCK (pY505)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around Y505 of human Lck.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P06239 (UniProt, ExPASy)
UniProt Entry Name	LCK_HUMAN
Gene Symbol	LCK
GeneID	3932
NCBI Accession	NP_001036236.1
KEGG	hsa:3932
String	9606.ENSP00000337825
Molecular Weight	Calculated MW: 58 kDa Observed MW: 56 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on LCK (pY505)

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