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Neutrophil Gelatinase Associated Lipocalin / NGAL (LCN2) Antibody

Catalogue No: abx002278
Price: £120.00
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Neutrophil Gelatinase Associated Lipocalin / NGAL (LCN2) Antibody

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NGAL/LCN2 Antibody is a Rabbit Polyclonal antibody against NGAL. Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis.

Target Neutrophil Gelatinase Associated Lipocalin / NGAL (LCN2)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human LCN2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P80188 (UniProt, ExPASy)
UniProt Entry Name NGAL_HUMAN
Gene Symbol LCN2
GeneID 3934
OMIM 600181
HGNC 6526
KEGG hsa:3934
Ensembl ENSG00000148346
String 9606.ENSP00000362108
Molecular Weight Calculated MW: 22 kDa
Observed MW: 22 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Neutrophil Gelatinase Associated Lipocalin / NGAL (LCN2) Antibody

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