Low Density Lipoprotein Receptor (LDLR) Antibody

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place.

Target	Low Density Lipoprotein Receptor (LDLR)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 391-419 amino acids from the Central region of human LDLR.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01130 (UniProt, ExPASy)
UniProt Entry Name	LDLR_HUMAN
Gene Symbol	LDLR
KEGG	hsa:3949
String	9606.ENSP00000454071
Molecular Weight	Calculated MW: 95.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat, Cow, Pig, Hamster and Xenopus LDLR.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Low Density Lipoprotein Receptor (LDLR)

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