Lymphoid Enhancer Binding Factor 1 (LEF1) Antibody
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Catalogue No: abx216546
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US$420.50
(Size: 100 µg)
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Datasheet SDS
Lymphoid Enhancer Binding Factor 1 (LEF1) Antibody is a Rabbit Polyclonal antibody for the detection of LEF1. Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Research Articles on Lymphoid Enhancer Binding Factor 1 (LEF1)
| Target | Lymphoid Enhancer Binding Factor 1 (LEF1) |
| Research Area | Tumor Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | lymphoid enhancer-binding factor 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 24 months |
| UniProt Primary AC | Q9UJU2 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DG38, B7Z8E2, E9PDK3, Q3ZCU4, Q9HAZ0 |
| UniProt Entry Name | LEF1_HUMAN |
| Gene Symbol | LEF1 |
| GeneID | 51176 |
| OMIM | 153245 |
| HGNC | 6551 |
| Ensembl | ENSG00000138795 |
| String | 9606.ENSP00000265165 |
| Molecular Weight | Observed MW: 45-50 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |