Lymphoid Enhancer Binding Factor 1 (LEF1) Antibody

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Target	Lymphoid Enhancer Binding Factor 1 (LEF1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 10-37 amino acids from the N-terminal region of human LEF1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UJU2 (UniProt, ExPASy)
UniProt Secondary AC	B4DG38, B7Z8E2, E9PDK3, Q3ZCU4, Q9HAZ0
UniProt Entry Name	LEF1_HUMAN
Gene Symbol	LEF1
String	9606.ENSP00000265165
Molecular Weight	Calculated MW: 44.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat LEF1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Lymphoid Enhancer Binding Factor 1 (LEF1)

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