Lymphoid Enhancer Binding Factor 1 (LEF1) Antibody

Catalogue No: abx000894
Price: £120.00
(Size: 20 µl)
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LEF1 Antibody is a Rabbit Polyclonal antibody against LEF1. Lymphoid enhancer-binding factor 1(LEF1) belongs to a family of regulatory protein share homology with high mobility group protein-1, and it's a nuclear protein exprssed in pre-B and T cells. LEF1 has a role in the Wnt signaling pathway and hair cell differentiation and follicle morphogenesis. Together with CTNNB1 and EP300, LEF1 activates transcription of target genes. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Target LEF1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human LEF1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9UJU2 (UniProt, ExPASy)
UniProt Secondary AC B4DG38, B7Z8E2, E9PDK3, Q3ZCU4, Q9HAZ0
UniProt Entry Name LEF1_HUMAN
Gene Symbol LEF1
GeneID 51176
String 9606.ENSP00000265165
Molecular Weight Calculated MW: 23 kDa, 31 kDa, 34 kDa, 35 kDa, 41 kDa, 42 kDa, 44 kDa
Observed MW: 40 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on LEF1

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