Leptin Receptor (LEPR) Antibody
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Catalogue No: abx002178
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US$348.00
(Size: 60 µl)
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Datasheet SDS
LEPR Antibody is a Rabbit Polyclonal antibody against LEPR. The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
Research Articles on Leptin Receptor (LEPR)
| Target | Leptin Receptor (LEPR) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human LEPR |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P48357 (UniProt, ExPASy) |
| UniProt Secondary AC | Q13592, Q13593, Q13594, Q92919, Q92920, Q92921 |
| Gene Symbol | LEPR |
| GeneID | 3953 |
| NCBI Accession | NP_002294.2 |
| KEGG | hsa:3953 |
| String | 9606.ENSP00000330393 |
| Molecular Weight | Calculated MW: 96 kDa/102 kDa/103 kDa/109 kDa/132 kDa Observed MW: 113 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
