Beta-1,3-N-Acetylglucosaminyltransferase Lunatic Fringe (LFNG) Antibody
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Catalogue No: abx034406
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US$326.25
(Size: 80 µl)
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Datasheet SDS
LFNG belongs to evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1, 3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This protein is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150).
Research Articles on Beta-1,3-N-Acetylglucosaminyltransferase Lunatic Fringe (LFNG)
| Target | Beta-1,3-N-Acetylglucosaminyltransferase Lunatic Fringe (LFNG) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 86-114 amino acids from the Central region of human LFNG. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q8NES3 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KTY6, B5MCR5, O00589, Q96C39, Q9UJW5 |
| UniProt Entry Name | LFNG_HUMAN |
| Gene Symbol | LFNG |
| KEGG | hsa:3955 |
| String | 9606.ENSP00000222725 |
| Molecular Weight | Calculated MW: 41.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |