Lectin-Galactoside Binding Soluble 3 (LGALS3) Antibody

Catalogue No: abx001250
Price: £120.00
(Size: 20 µl)
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LGALS3 Antibody is a Rabbit Polyclonal antibody against LGALS3. Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of ∫1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn’s disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.

Target LGALS3
Clonality Polyclonal
Reactivity Human, Rat
Tested Applications IHC, IF/ICC
Host Rabbit
Recommended dilutions IHC: 1/50 - 1/200, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human LGALS3.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P17931 (UniProt, ExPASy)
UniProt Secondary AC B2RC38, Q16005, Q6IBA7, Q96J47
UniProt Entry Name LEG3_HUMAN
Gene Symbol LGALS3
GeneID 3958
KEGG hsa:3958
String 9606.ENSP00000254301
Molecular Weight Calculated MW: 26 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on LGALS3

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