DNA Ligase 3 (LIG3) Antibody

LIG3 Antibody is a Rabbit Polyclonal antibody against LIG3. This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

Target	DNA Ligase 3 (LIG3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 730-1009 of human DNA Ligase III/LIG3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49916 (UniProt, ExPASy)
UniProt Secondary AC	E5KLB5, E5KLB6, Q16714, Q6NVK3
UniProt Entry Name	DNLI3_HUMAN
Gene Symbol	LIG3
GeneID	3980
NCBI Accession	NP_039269.2
KEGG	hsa:3980
String	9606.ENSP00000367787
Molecular Weight	Calculated MW: 113 kDa Observed MW: 113 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on DNA Ligase 3 (LIG3)

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