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DNA Ligase 4 (LIG4) Antibody

Catalogue No: abx001451
Price: £120.00
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DNA Ligase 4 (LIG4) Antibody

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LIG4 Antibody is a Rabbit Polyclonal antibody against LIG4. Two major pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ), counteract one of themost toxic lesions, the DSB. The core protein complex mediating NHEJ in mammals includes DNA ligase IV (Lig4). Lig4 belongs to an ATP-dependent DNA ligase family, and joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. The complex Lig4-XRCC4 is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of Lig4.

Target LIG4
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human LIG4.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P49917 (UniProt, ExPASy)
UniProt Secondary AC Q8IY66, Q8TEU5
UniProt Entry Name DNLI4_HUMAN
Gene Symbol LIG4
GeneID 3981
KEGG hsa:3981
String 9606.ENSP00000484288
Molecular Weight Calculated MW: 103 kDa
Observed MW: 108 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on DNA Ligase 4 (LIG4) Antibody

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