DNA Ligase 4 (LIG4) Antibody
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Catalogue No: abx001451
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US$217.50
(Size: 20 µl)
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Datasheet SDS
LIG4 Antibody is a Rabbit Polyclonal antibody against LIG4. Two major pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ), counteract one of themost toxic lesions, the DSB. The core protein complex mediating NHEJ in mammals includes DNA ligase IV (Lig4). Lig4 belongs to an ATP-dependent DNA ligase family, and joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. The complex Lig4-XRCC4 is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of Lig4.
Research Articles on DNA Ligase 4 (LIG4)
| Target | DNA Ligase 4 (LIG4) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to LIG4. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P49917 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8IY66, Q8TEU5 |
| UniProt Entry Name | DNLI4_HUMAN |
| Gene Symbol | LIG4 |
| GeneID | 3981 |
| NCBI Accession | NP_002303.2 |
| KEGG | hsa:3981 |
| String | 9606.ENSP00000484288 |
| Molecular Weight | Calculated MW: 104 kDa Observed MW: 110 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |