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LIMK2 (pT505) Antibody

Catalogue No: abx000435
Price: £220.00
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LIMK2 (pT505) Antibody LIMK2 (pT505) Antibody

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LIMK2 (pT505) Antibody is a Rabbit Polyclonal antibody against LIMK2 (pT505). There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

Target LIMK2 (pT505)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding T505 of human LIMK2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P53671 (UniProt, ExPASy)
UniProt Secondary AC A8K6H5, Q7KZ80, Q7L3H5, Q96E10, Q99464, Q9UFU0
UniProt Entry Name LIMK2_HUMAN
Gene Symbol LIMK2
GeneID 3985
String 9606.ENSP00000339916
Molecular Weight Calculated MW: 69 kDa, 72 kDa, 77 kDa
Observed MW: 72 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on LIMK2 (pT505) Antibody

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