Linker For Activation Of T-Cell (LAT) Antibody

Linker For Activation Of T-Cell (LAT) Antibody is a Rabbit Polyclonal antibody for the detection of LAT.

Required for TCR (T-cell antigen receptor) -and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III) -mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Target	Linker For Activation Of T-Cell (LAT)
Research Area	Metabolism, Developmental Science, Nutrition, Bone Metabolism
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	linker for activation of T cells
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Shelf Life	24 months
UniProt Primary AC	O43561 (UniProt, ExPASy)
UniProt Secondary AC	B7WPI0, C7C5T6, G5E9K3, O43919
UniProt Entry Name	LAT_HUMAN
Gene Symbol	LAT
GeneID	27040
OMIM	602354
HGNC	18874
KEGG	hsa:27040
Ensembl	ENSG00000213658
Molecular Weight	Observed MW: 36-38 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on Linker For Activation Of T-Cell (LAT)

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