Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Factor (LITAF) Antibody

LITAF Antibody is a Rabbit Polyclonal antibody against LITAF. Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.

Target	Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Factor (LITAF)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IHC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IP: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human LITAF.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q99732 (UniProt, ExPASy)
UniProt Secondary AC	D3DUG1, G5E9K0, Q05DW0, Q9C0L6
UniProt Entry Name	LITAF_HUMAN
Gene Symbol	LITAF
GeneID	9516
NCBI Accession	NP_004853.2
KEGG	hsa:9516
String	9606.ENSP00000459533
Molecular Weight	Calculated MW: 17 kDa Observed MW: 23 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Factor (LITAF)

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