Lamin B1 (LMNB1) Antibody

LMNB1 Antibody is a Rabbit Polyclonal antibody against LMNB1. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

Target	Lamin B1 (LMNB1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts, ChIP: 5 µg/10-15 µg Chromatin. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 397-586 of human Lamin B1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P20700 (UniProt, ExPASy)
UniProt Secondary AC	B2R6J6, Q3SYN7, Q96EI6
UniProt Entry Name	LMNB1_HUMAN
Gene Symbol	LMNB1
GeneID	4001
NCBI Accession	NP_005564.1
KEGG	hsa:4001
String	9606.ENSP00000261366
Molecular Weight	Calculated MW: 66 kDa Observed MW: 68/45 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Lamin B1 (LMNB1)

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