Proteasome Subunit Beta Type 8 (PSMB8) Antibody

Proteasome Subunit Beta Type 8 (PSMB8) Antibody is a Goat Polyclonal antibody against Proteasome Subunit Beta Type 8 (PSMB8). The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Target	Proteasome Subunit Beta Type 8 (PSMB8)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	P-ELISA, WB, IHC
Host	Goat
Recommended dilutions	P-ELISA: 1/8000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	C-Terminus: C-DVSDLLHQYREANQ
Isotype	IgG
Form	Liquid
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P28062 (UniProt, ExPASy)
UniProt Secondary AC	B0UZC0, Q29824, Q5JNW6, Q5QNR8, Q96J48
UniProt Entry Name	PSB8_HUMAN
Gene Symbol	PSMB8
GeneID	5696 16913 24968
OMIM	177046
NCBI Accession	NP_004150.1 NP_683720.2
KEGG	hsa:5696
String	9606.ENSP00000364016
Buffer	Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Concentration	0.5 mg/ml
Availability	Shipped within 1-3 working days.
Note	This product is for research use only.

Research Articles on Proteasome Subunit Beta Type 8 (PSMB8)

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