Protein-Lysine 6-Oxidase (LOX) Antibody

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product.

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. This antibody is supplied as crude ascites.

Target	Protein-Lysine 6-Oxidase (LOX)
Research Area	Enzymes and Kinases
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/200 - 1/1600. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.
Isotype	IgG2b
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles.
Shelf Life	12 months.
UniProt Primary AC	P28300 (UniProt, ExPASy)
UniProt Secondary AC	B2R5Q3, Q5FWF0
UniProt Entry Name	LYOX_HUMAN
KEGG	hsa:4015
String	9606.ENSP00000231004
Molecular Weight	Calculated MW: 46.9 kDa
Buffer	Ascites containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Pig LOX.
Availability	Please enquire.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on Protein-Lysine 6-Oxidase (LOX)

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