Low Density Lipoprotein Receptor Related Protein 5 (LRP5) Antibody

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

Target	Low Density Lipoprotein Receptor Related Protein 5 (LRP5)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human LRP5 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O75197 (UniProt, ExPASy)
UniProt Secondary AC	Q96TD6, Q9UES7, Q9UP66
UniProt Entry Name	LRP5_HUMAN
Gene Symbol	LRP5
GeneID	4041
OMIM	133780
HGNC	6697
KEGG	hsa:4041
Ensembl	ENSG00000162337
String	9606.ENSP00000294304
Molecular Weight	179 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Low Density Lipoprotein Receptor Related Protein 5 (LRP5)

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