Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Antibody
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Catalogue No: abx004691
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US$348.00
(Size: 60 µl)
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Datasheet SDS
LRP6 Antibody is a Rabbit Polyclonal antibody against LRP6. This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Research Articles on Low Density Lipoprotein Receptor Related Protein 6 (LRP6)
| Target | Low Density Lipoprotein Receptor Related Protein 6 (LRP6) |
| Research Area | Metabolism |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | IF/ICC |
| Host | Rabbit |
| Recommended dilutions | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human LRP6 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O75581 (UniProt, ExPASy) |
| UniProt Secondary AC | Q17RZ2 |
| UniProt Entry Name | LRP6_HUMAN |
| Gene Symbol | LRP6 |
| GeneID | 4040 |
| NCBI Accession | NP_002327.2 |
| KEGG | hsa:4040 |
| String | 9606.ENSP00000261349 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
