Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) Antibody

This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Target	Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 782-810 amino acids from the C-terminal region of human LRRC8A.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8IWT6 (UniProt, ExPASy)
UniProt Secondary AC	Q6UXM2, Q8NCI0, Q9P2B1
UniProt Entry Name	LRC8A_HUMAN
Gene Symbol	LRRC8A
KEGG	hsa:56262
String	9606.ENSP00000259324
Molecular Weight	Calculated MW: 94.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat LRRC8A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A)

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