Lysine-Specific Histone Demethylase 1A (LSD1) Antibody

LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.

Target	Lysine-Specific Histone Demethylase 1A (LSD1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 457-490 amino acids from the Central region of human LSD1.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O60341 (UniProt, ExPASy)
UniProt Entry Name	KDM1A_HUMAN
KEGG	hsa:23028
String	9606.ENSP00000383042
Molecular Weight	Calculated MW: 92.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse KDM1A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Lysine-Specific Histone Demethylase 1A (LSD1)

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