Melanoma-Associated Antigen D1 (MAGED1) Antibody
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Catalogue No: abx001013
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US$348.00
(Size: 60 µl)
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Datasheet SDS
MAGED1 Antibody is a Rabbit Polyclonal antibody against MAGED1. MAGE-D1, also known as NRAGE or Dlxin-1, is a member of the MAGE family of proteins. Identified as a p75 neurotrophin receptor intracellular binding protein, MAGE-D1 induces developmental apoptosis of motoneurons, and is required for p75NTR-dependent apoptosis in sympathetic neurons. It is suggested that MAGE-D1 can suppress the motility and adhesion response of tumor cells. By forming a hetercomplex with Dlx/Msx family homeodomain proteins and Necdin, MAGE-D1 modulates the function of Dlx/Msx homeodomain during terminal differentiation and maturation of neurons. MAGE-D1 is also involved in the phosphorylation of IKK-alpha/beta, and subsequent transcriptional activation of the p65 subunit of NF-kappaB, via the XIAP-Tak1-Tab1 complex. (20100315, 19639218, 17453828, 15272023) G.
Research Articles on Melanoma-Associated Antigen D1 (MAGED1)
| Target | Melanoma-Associated Antigen D1 (MAGED1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human MAGED1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9Y5V3 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36 |
| UniProt Entry Name | MAGD1_HUMAN |
| Gene Symbol | MAGED1 |
| GeneID | 9500 |
| NCBI Accession | NP_001005333.1 |
| String | 9606.ENSP00000364847 |
| Molecular Weight | Calculated MW: 86 kDa/91 kDa Observed MW: 86 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
