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Melanoma-Associated Antigen D1 (MAGED1) Antibody

Catalogue No: abx001013
Price: £120.00
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Melanoma-Associated Antigen D1 (MAGED1) Antibody

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MAGED1 Antibody is a Rabbit Polyclonal antibody against MAGED1. MAGE-D1, also known as NRAGE or Dlxin-1, is a member of the MAGE family of proteins. Identified as a p75 neurotrophin receptor intracellular binding protein, MAGE-D1 induces developmental apoptosis of motoneurons, and is required for p75NTR-dependent apoptosis in sympathetic neurons. It is suggested that MAGE-D1 can suppress the motility and adhesion response of tumor cells. By forming a hetercomplex with Dlx/Msx family homeodomain proteins and Necdin, MAGE-D1 modulates the function of Dlx/Msx homeodomain during terminal differentiation and maturation of neurons. MAGE-D1 is also involved in the phosphorylation of IKK-alpha/beta, and subsequent transcriptional activation of the p65 subunit of NF-kappaB, via the XIAP-Tak1-Tab1 complex. (20100315, 19639218, 17453828, 15272023) G.

Target MAGED1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human MAGED1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9Y5V3 (UniProt, ExPASy)
UniProt Secondary AC Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36
UniProt Entry Name MAGD1_HUMAN
Gene Symbol MAGED1
GeneID 9500
String 9606.ENSP00000364847
Molecular Weight Calculated MW: 86 kDa, 91 kDa
Observed MW: 86 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Melanoma-Associated Antigen D1 (MAGED1) Antibody

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