MAP2K3 (pS189) Antibody

MAP2K3 (pS189) Antibody is a Rabbit Polyclonal antibody against MAP2K3 (pS189). MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK. Phosphorylation of p38 MAP kinase dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines. Activation of MKK3 and MKK6 occurs through phosphorylation of Ser189 and Thr193 on MKK3 and Ser207 and Thr211 on MKK6.

Target	MAP2K3 (pS189)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S189 of human MAP2K6MAP2K3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P46734 (UniProt, ExPASy) P52564 (UniProt, ExPASy)
UniProt Secondary AC	B3KSK7, Q99441, Q9UE71, Q9UE72
UniProt Entry Name	MP2K3_HUMAN
Gene Symbol	MAP2K3, MAP2K6
GeneID	5606
NCBI Accession	NP_002747.2
String	9606.ENSP00000345083
Molecular Weight	Calculated MW: 36/39/31/37 kDa Observed MW: 40/41 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on MAP2K3 (pS189)

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