Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Antibody

MAP2K4 (mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified.MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases.MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors.By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation.Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.

Target	Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of MAP2K4 expressed in E. coli.
Isotype	IgM
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P45985 (UniProt, ExPASy)
UniProt Secondary AC	B2R7N7, B3KYB2, D3DTS5, Q5U0B8, Q6FHX4, Q6P9H2, Q6PIE6
UniProt Entry Name	MP2K4_HUMAN
Gene Symbol	MAP2K4
GeneID	6416
OMIM	601335
HGNC	6844
KEGG	hsa:6416
Ensembl	ENSG00000065559
String	9606.ENSP00000410402
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4)

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