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Apoptosis Signal Regulating Kinase 1 (MAP3K5) Antibody

Catalogue No: abx000666
Price: £120.00
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Apoptosis Signal Regulating Kinase 1 (MAP3K5) Antibody

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MAP3K5 Antibody is a Rabbit Polyclonal antibody against MAP3K5. Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.

Target MAP3K5
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human MAP3K5.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q99683 (UniProt, ExPASy)
UniProt Secondary AC A6NIA0, B4DGB2, Q5THN3, Q99461
UniProt Entry Name M3K5_HUMAN
Gene Symbol MAP3K5
GeneID 4217
KEGG hsa:4217
String 9606.ENSP00000351908
Molecular Weight Calculated MW: 69 kDa, 154 kDa
Observed MW: 150 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Apoptosis Signal Regulating Kinase 1 (MAP3K5) Antibody

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