MEK Kinase Kinase 3 (MAP4K3) Antibody
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Catalogue No: abx034546
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US$326.25
(Size: 80 µl)
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Datasheet SDS
MAP4K3 encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).
Research Articles on MEK Kinase Kinase 3 (MAP4K3)
| Target | MEK Kinase Kinase 3 (MAP4K3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein encoding human MAP4K3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by protein affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q8IVH8 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6IQ39, Q8IVH7, Q9UDM5, Q9Y6R5 |
| UniProt Entry Name | M4K3_HUMAN |
| Gene Symbol | MAP4K3 |
| NCBI Accession | NP_001257354.1 NP_003609.2 |
| KEGG | hsa:8491 |
| String | 9606.ENSP00000263881 |
| Molecular Weight | Calculated MW: 101 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |