Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) Antibody
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Catalogue No: abx033443
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US$326.25
(Size: 80 µl)
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Datasheet SDS
JNK3 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
Research Articles on Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10)
| Target | Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) |
| Research Area | Enzymes and Kinases, Infection Immunity |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MAPK10. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P53779 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NFS3, A6NG28, B3KQ94, Q15707, Q49AP1 |
| UniProt Entry Name | MK10_HUMAN |
| NCBI Accession | NP_002744.1 NP_620446.1 NP_620447.1 NP_620448.1 |
| KEGG | hsa:5602 |
| String | 9606.ENSP00000352157 |
| Molecular Weight | Calculated MW: 52.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |