Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) Antibody

JNK3 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.

Target	Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MAPK10.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P53779 (UniProt, ExPASy)
UniProt Secondary AC	A6NFS3, A6NG28, B3KQ94, Q15707, Q49AP1
UniProt Entry Name	MK10_HUMAN
NCBI Accession	NP_002744.1 NP_620446.1 NP_620447.1 NP_620448.1
KEGG	hsa:5602
String	9606.ENSP00000352157
Molecular Weight	Calculated MW: 52.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10)

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