Mitogen-Activated Protein Kinase 15 (MAPK15) Antibody

The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.

Target	Mitogen-Activated Protein Kinase 15 (MAPK15)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human MAPK15.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8TD08 (UniProt, ExPASy)
UniProt Secondary AC	Q2TCF9, Q8N362
UniProt Entry Name	MK15_HUMAN
KEGG	hsa:225689
String	9606.ENSP00000337691
Molecular Weight	Calculated MW: 59.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mitogen-Activated Protein Kinase 15 (MAPK15)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue