Mitogen-Activated Protein Kinase 3 / ERK1 (MAPK3) Antibody

ERK1, a member of the MAP kinase subfamily of Ser/Thr protein kinases, is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. It phosphorylates EIF4EBP1 and is required for initiation of translation. The protein also phosphorylates microtubule-associated protein-2 (MAP2). ERK1 is activated and tyrosine phosphorylated in response to insulin and NGF.

Target	Mitogen-Activated Protein Kinase 3 / ERK1 (MAPK3)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat, Monkey
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MAPK3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P27361 (UniProt, ExPASy)
UniProt Secondary AC	A8CZ58, B0LPG3, Q8NHX1
UniProt Entry Name	MK03_HUMAN
KEGG	hsa:5595
String	9606.ENSP00000263025
Molecular Weight	Calculated MW: 43.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mitogen-Activated Protein Kinase 3 / ERK1 (MAPK3)

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