The protein encoded by this gene is a member of the MAP kinase family.MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli.The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis.This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway.Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Target |
Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8) |
Clonality |
Monoclonal |
Reactivity |
Human, Mouse |
Tested Applications |
ELISA, WB, FCM |
Host |
Mouse |
Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Purified recombinant fragment of human MAPK8 expressed in E. coli. |
Isotype |
IgG1 |
Form |
Liquid |
Purification |
Purified from ascites by Protein G chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
GeneID |
5599
|
Molecular Weight |
48.3 kDa |
Buffer |
PBS, containing 0.05% sodium azide. |
Concentration |
1 mg/ml |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8)