Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8) Antibody

Catalogue No: abx015921
Price: £290.00
(Size: 100 µl)

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Datasheet SDS
The protein encoded by this gene is a member of the MAP kinase family.MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli.The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis.This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway.Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Target Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8)
Clonality Monoclonal
Reactivity Human, Mouse
Tested Applications ELISA, WB, FCM
Host Mouse
Recommended dilutions ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human MAPK8 expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Purified from ascites by Protein G chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
GeneID 5599
Molecular Weight 48.3 kDa
Buffer PBS, containing 0.05% sodium azide.
Concentration 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8)

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