Mitogen-Activated Protein Kinase 8/9/10 Phospho-Thr183/Tyr185/Thr221 (MAPK8/9/10 pT183/Y185/T221) Antibody

MAPK8/9/10 (pT183/Y185/T221) Antibody is a Rabbit Polyclonal antibody against MAPK8 (pT183/Y185), MAPK9 (pT183/Y185) and MAPK10 (T221). Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: a-1 and a-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 a-2, and JUND binds only weakly to it. /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity.

Target	Mitogen-Activated Protein Kinase 8/9/10 Phospho-Thr183/Tyr185/Thr221 (MAPK8/9/10 pT183/Y185/T221)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A phospho specific peptide corresponding to residues surrounding T183 of human JNK1
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P45983 (UniProt, ExPASy) P45984 (UniProt, ExPASy) P53779 (UniProt, ExPASy)
Gene Symbol	MAPK8, MAPK9, MAPK10
GeneID	5599/5601/5602
Molecular Weight	Calculated MW: 35/44/48/27/52 kDa Observed MW: 46 kDa, 54 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mitogen-Activated Protein Kinase 8/9/10 Phospho-Thr183/Tyr185/Thr221 (MAPK8/9/10 pT183/Y185/T221)

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