Microtubule-Associated Protein Tau (MAPT) Antibody

MAPT Antibody is a Rabbit Polyclonal antibody against MAPT. This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Target	Microtubule-Associated Protein Tau (MAPT)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500, IHC-P: 1/100 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 658-758 of human Tau.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10636 (UniProt, ExPASy)
UniProt Secondary AC	P18518, Q14799, Q15549, Q15550, Q15551, Q1RMF6, Q53YB1, Q5CZI7, Q5XWF0, Q6QT54, Q9UDJ3, Q9UMH0, Q9UQ96
UniProt Entry Name	TAU_HUMAN
Gene Symbol	MAPT
GeneID	4137
OMIM	157140
NCBI Accession	NP_058519.3
HGNC	6893
KEGG	hsa:4137
Ensembl	ENSG00000186868
String	9606.ENSP00000340820
Molecular Weight	Calculated MW: 79 kDa Observed MW: 45-75 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Microtubule-Associated Protein Tau (MAPT)

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