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Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody

Catalogue No: abx001828
Price: £120.00
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Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody

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MBD2 Antibody is a Rabbit Polyclonal antibody against MBD2. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Target MBD2
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/200 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human MBD2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9UBB5 (UniProt, ExPASy)
UniProt Secondary AC O95242, Q9UIS8
UniProt Entry Name MBD2_HUMAN
Gene Symbol MBD2
GeneID 8932
String 9606.ENSP00000256429
Molecular Weight Calculated MW: 31 kDa, 43 kDa
Observed MW: 53 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody

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