Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody

MBD3 Antibody is a Rabbit Polyclonal antibody against MBD3. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.

Target	Methyl-CpG Binding Domain Protein 3 (MBD3)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human MBD3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95983 (UniProt, ExPASy)
UniProt Secondary AC	A8K4B7, D6W5Z2, Q6PIL9, Q6PJZ9, Q86XF4
UniProt Entry Name	MBD3_HUMAN
Gene Symbol	MBD3
GeneID	53615
NCBI Accession	NP_001268383.1
KEGG	hsa:53615
String	9606.ENSP00000412302
Molecular Weight	Calculated MW: 33 kDa Observed MW: 36 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Methyl-CpG Binding Domain Protein 3 (MBD3)

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