Myelin Basic Protein (MBP) Antibody
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Catalogue No: abx011639
Price:
US$427.75
(Size: 100 µl)
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Datasheet SDS
The classic group of MBP isoforms (isoforms 4-14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoforms 1-3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
Research Articles on Myelin Basic Protein (MBP)
| Target | Myelin Basic Protein (MBP) |
| Research Area | Enzymes and Kinases, Infection Immunity |
| Clonality | Monoclonal |
| Reactivity | General (All species) |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein with Maltose binding protein tag. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P02686 (UniProt, ExPASy) |
| UniProt Entry Name | MBP_HUMAN |
| Gene Symbol | MBP |
| GeneID | 4155 |
| OMIM | 159430 |
| HGNC | 6925 |
| KEGG | hsa:4155 |
| Ensembl | ENSG00000197971 |
| String | 9606.ENSP00000380958 |
| Molecular Weight | 33 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |