Myelin Basic Protein (MBP) Antibody

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.However, MBP-related transcripts are also present in the bone marrow and the immune system.These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons.Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products.The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons.They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence.The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins.This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Target	Myelin Basic Protein (MBP)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human MBP expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P02686 (UniProt, ExPASy)
UniProt Entry Name	MBP_HUMAN
Gene Symbol	MBP
GeneID	4155
OMIM	159430
HGNC	6925
KEGG	hsa:4155
Ensembl	ENSG00000197971
String	9606.ENSP00000380958
Molecular Weight	33 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Myelin Basic Protein (MBP)

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