Melanocyte-Stimulating Hormone Receptor (MC1R) Antibody
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Price:
US$326.25
(Size: 80 µl)
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This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq].
Target |
Melanocyte-Stimulating Hormone Receptor (MC1R) |
Clonality |
Monoclonal |
Reactivity |
Human |
Tested Applications |
ELISA, WB |
Host |
Mouse |
Recommended dilutions |
WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
KLH-conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R. |
Isotype |
IgM |
Form |
Liquid |
Purification |
Purified Mouse Monoclonal Antibody. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
Q01726 (UniProt,
ExPASy)
|
UniProt Entry Name |
MSHR_HUMAN |
KEGG |
hsa:4157
|
String |
9606.ENSP00000451605
|
Molecular Weight |
Calculated MW: 34.7 kDa |
Buffer |
PBS containing 0.09% sodium azide. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Melanocyte-Stimulating Hormone Receptor (MC1R)